Antioxidants, Vol. 12, Pages 462: Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

Antioxidants, Vol. 12, Pages 462: Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

Antioxidants doi: 10.3390/antiox12020462

Authors: D. Allan Butterfield

Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.