Applied Sciences, Vol. 13, Pages 6376: RNA Modification Related Diseases and Sensing Methods

Applied Sciences, Vol. 13, Pages 6376: RNA Modification Related Diseases and Sensing Methods

Applied Sciences doi: 10.3390/app13116376

Authors: Mayuka Ohkawa Masamitsu Konno

Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the immune system, and various life phenomena such as cancer, neurological diseases, and infectious diseases. However, a major problem is the development of sequencing methods to map RNA base modifications throughout the transcriptome. In recent years, various methods for RNA base modification have been actively studied, and we are beginning to successfully measure base modifications that have been difficult to measure in previous years. In this review, we will discuss in detail the biological significance of RNA modifications and the latest techniques for detecting RNA modifications.