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Biomimetics, Vol. 8, Pages 565: Porous Polylactide Microparticles as Effective Fillers for Hydrogels
Biomimetics doi: 10.3390/biomimetics8080565
Authors: Yuriy D. Zagoskin Yana E. Sergeeva Yuliya S. Fomina Daniil V. Sukhinov Sergey N. Malakhov Egor O. Osidak Elena A. Khramtsova Pavel M. Gotovtsev Sergei N. Chvalun Timofei E. Grigoriev
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values of over 98%. The elastic modulus of hydrogels depended on the filler concentration. The modulus increased from 80 kPa to 400–600 kPa at a concentration of porous particles of 12–15 wt.% and up to 1.8 MPa at a filling of 20–25 wt.% for collagen hydrogels. The elastic modulus of the chitosan–genipin hydrogel increases from 75 kPa to 900 kPa at a fraction of particles of 20 wt.%. These elastic modulus values cover a range of strength properties from connective tissue to cartilage tissue. It is important to note that the increase in strength in this case is accompanied by a decrease in the density of the material, that is, an increase in porosity. PLA particles were loaded with C-phycocyanin and showed an advanced release profile up to 48 h. Thus, composite hydrogels mimic the structure, biomechanics and release of biomolecules in the tissues of a living organism.
