Biosensors, Vol. 14, Pages 586: 2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-C3N4-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride

Biosensors, Vol. 14, Pages 586: 2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-C3N4-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride

Biosensors doi: 10.3390/bios14120586

Authors: Xiaowei Fan Guping Zhang Xiaodi Li Yao Wang Yi Wang Shilei Hao Defang Liu

In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-C3N4/S2O82− system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant–product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the S2O82− into SO4•− and enhancing the cathodic ECL emission of g-C3N4. Moreover, the signal probe which was synthesized by coupling the 2D CdS@Co/Mo-MOF and graphitic carbon nitride (g-C3N4) achieved the generation of SO4•− in situ and reduced energy loss. The results confirmed that the ECL signal was enhanced 6.2-fold and stabilized by CdS@Co/Mo-MOF. Based on the extremely strong quenching effect of chlorpromazine hydrochloride (CPH) on this system, a “signal-off” type sensor was constructed. The sensor demonstrated excellent sensitivity and linear response to CPH concentrations ranging from 1 pmol L−1 to 100 μmol L−1, with a low detection limit of 0.4 pmol L−1 (S/N = 3).