Current Oncology, Vol. 31, Pages 7190-7203: Soft Tissue Reconstruction and Integration to Implant After Bone-Tumor Resection: A Current Concept Review

Current Oncology, Vol. 31, Pages 7190-7203: Soft Tissue Reconstruction and Integration to Implant After Bone-Tumor Resection: A Current Concept Review

Current Oncology doi: 10.3390/curroncol31110531

Authors: Elisa Pesare Raffaele Vitiello Tommaso Greco Giuseppe Solarino Giulio Maccauro Antonio Ziranu

Introduction: With the advancements in chemotherapy for malignant bone tumors, the number of patients eligible for limb salvage surgery has increased. Surgeons face a subsequent challenge in limb-sparing resection due to the need for reconstructing soft tissue coverage. The aim of this review is to focus on the present state of the field in these areas, highlighting recent advancements. Methods: A literature research was conducted using keywords such as “soft tissue”, “integration”, “reconstruction”, “megaprosthesis”, and “soft tissue coverage”, on different databases, and following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria, a total of 35 studies were selected. Results: In recent times, there has been a growing emphasis on different techniques such mesh application, allograft-prosthesis composites, allograft reconstruction, a polyethylene terephthalate (PET) tube, prosthesis itself and certain metals utilized for implant coatings are used in soft tissue reconstruction. Conclusion: While tissue-engineered constructs and advancements in biological and cellular approaches have shown potential for enhancing osseointegration and interactions with soft tissues and implants, the actual clinical outcomes have frequently fallen short of expectations. The success of soft tissue integration is crucial for achieving functional outcomes, minimizing complications, and ensuring the long-term stability of orthopedic implants.