The ways in which societies, institutions and citizens relate to and value nature have played a key role in the interconnected biodiversity, climate change, natural resource and health crises we face. This briefing explores how to reframe the relationships between humans and nature. It examines how holistically understanding humans’ deep interconnection with other life forms and ecosystems could lead to new motivations to protect nature and accelerate the societal transformation we need to live well within the limits of the planet.