Gastrointestinal Disorders, Vol. 6, Pages 796-800: Squamous Cell Carcinoma of the Gallbladder Masquerading as Complicated Cholecystitis: A Case Report and Review

Gastrointestinal Disorders, Vol. 6, Pages 796-800: Squamous Cell Carcinoma of the Gallbladder Masquerading as Complicated Cholecystitis: A Case Report and Review

Gastrointestinal Disorders doi: 10.3390/gidisord6030055

Authors: Najib Bahrou El Khalil Cherif Salah Abdenbi Yahya Zain Al Abidine Khedid Mohamed El Absi El Mahjoub Echarrab Mohamed Elounani El Alami El Faricha El Hassan

In summary, squamous cell carcinoma (SCC) of the gallbladder, although rare, poses significant diagnostic and therapeutic challenges. We report the case of a 51-year-old woman with no previous medical history, with SCC discovered during complicated cholecystitis with cholangitis, treated by palliative chemotherapy, underscoring the difficulty in early detection and the poor prognosis associated with advanced-stage diagnosis. Treatment options are limited, with palliative chemotherapy often being the primary recourse for unresectable tumors. Gallbladder cancers, including SCC, share risk factors with adenocarcinomas, but their distinct histopathological features and clinical presentations warrant careful consideration. Despite recent advancements in treatment modalities, including adjuvant therapy, optimal management strategies remain elusive, highlighting the need for further research to improve outcomes for patients with this aggressive malignancy.