Genes, Vol. 14, Pages 259: Progress of Endogenous and Exogenous Nanoparticles for Cancer Therapy and Diagnostics

Genes, Vol. 14, Pages 259: Progress of Endogenous and Exogenous Nanoparticles for Cancer Therapy and Diagnostics

Genes doi: 10.3390/genes14020259

Authors: Hideaki Fujita Seiichi Ohta Noriko Nakamura Masaharu Somiya Masanobu Horie

The focus of this brief review is to describe the application of nanoparticles, including endogenous nanoparticles (e.g., extracellular vesicles, EVs, and virus capsids) and exogenous nanoparticles (e.g., organic and inorganic materials) in cancer therapy and diagnostics. In this review, we mainly focused on EVs, where a recent study demonstrated that EVs secreted from cancer cells are associated with malignant alterations in cancer. EVs are expected to be used for cancer diagnostics by analyzing their informative cargo. Exogenous nanoparticles are also used in cancer diagnostics as imaging probes because they can be easily functionalized. Nanoparticles are promising targets for drug delivery system (DDS) development and have recently been actively studied. In this review, we introduce nanoparticles as a powerful tool in the field of cancer therapy and diagnostics and discuss issues and future prospects.