IJMS, Vol. 24, Pages 10705: Endothelial Dysfunction in Diabetes Mellitus: New Insights

IJMS, Vol. 24, Pages 10705: Endothelial Dysfunction in Diabetes Mellitus: New Insights

International Journal of Molecular Sciences doi: 10.3390/ijms241310705

Authors: Michal Dubsky Jiri Veleba Dominika Sojakova Natalia Marhefkova Vladimira Fejfarova Edward B. Jude

Endothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and severity of ED and its consequences. We highlight that data on ED in type 1 diabetes are lacking and discuss the relationship between ED and arterial stiffness. Several interesting studies have been published showing that ED modulates microRNA, microvesicles, lipid levels, and the endoplasmatic reticulum. A better understanding of ED could provide important insights into the microvascular complications of diabetes, their treatment, and even their prevention.