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IJMS, Vol. 24, Pages 3281: The Role of Liquid–Liquid Phase Separation in Actin Polymerization
International Journal of Molecular Sciences doi: 10.3390/ijms24043281
Authors: Olga I. Povarova Iuliia A. Antifeeva Alexander V. Fonin Konstantin K. Turoverov Irina M. Kuznetsova
To date, it has been shown that the phenomenon of liquid–liquid phase separation (LLPS) underlies many seemingly completely different cellular processes. This provided a new idea of the spatiotemporal organization of the cell. The new paradigm makes it possible to provide answers to many long-standing, but still unresolved questions facing the researcher. In particular, spatiotemporal regulation of the assembly/disassembly of the cytoskeleton, including the formation of actin filaments, becomes clearer. To date, it has been shown that coacervates of actin-binding proteins that arise during the phase separation of the liquid–liquid type can integrate G-actin and thereby increase its concentration to initiate polymerization. It has also been shown that the activity intensification of actin-binding proteins that control actin polymerization, such as N-WASP and Arp2/3, can be caused by their integration into liquid droplet coacervates formed by signaling proteins on the inner side of the cell membrane.
