IJMS, Vol. 24, Pages 9223: Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

IJMS, Vol. 24, Pages 9223: Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

International Journal of Molecular Sciences doi: 10.3390/ijms24119223

Authors: Flavia Tasmin Techera Antunes Maria Martha Campos Vanice de Paula Ricardo Carvalho Claudio Antonio da Silva Junior Luiz Alexandre Viana Magno Alessandra Hubner de Souza Marcus Vinicius Gomez

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.