JCDD, Vol. 11, Pages 332: Device-Assisted Left Atrial Appendage Exclusion: From Basic Sciences to Clinical Applications

JCDD, Vol. 11, Pages 332: Device-Assisted Left Atrial Appendage Exclusion: From Basic Sciences to Clinical Applications

Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd11100332

Authors: Julia Izabela Karpierz Michał Piotrowski Krzysztof Bartuś Radosław Chmiel Katarzyna Wijatkowska Artur Słomka

Device-assisted left atrial appendage exclusion plays a crucial role in the prevention of fatal ischemic complications in patients with atrial fibrillation and contraindications to anticoagulation treatment. Various devices with different safety profiles and device-related complications are available in daily practice to perform this procedure. In this review, the anatomy, physiology, and functions of the left atrial appendage were detailed, and all available devices used for epicardial and endocardial exclusion of the left atrial appendage and their clinical outcomes were discussed. Future research should aim to further investigate the long-term effects of left atrial appendage exclusion on body homeostasis, blood coagulation, and cardiac function.