JCTO, Vol. 1, Pages 35-51: The Activity of Substance P (SP) on the Corneal Epithelium

JCTO, Vol. 1, Pages 35-51: The Activity of Substance P (SP) on the Corneal Epithelium

Journal of Clinical & Translational Ophthalmology doi: 10.3390/jcto1020006

Authors: Jonathan Kopel Caezaan Keshvani Kelly Mitchell Ted Reid

In 1931, Von Euler and Gaddum isolated substance P (SP), an undecapeptide from the tachykinin family, from equine brain and intestine tissue extracts. Numerous types of cells, including neurons, astrocytes, microglia, epithelial, and endothelial cells, as well as immune cells including T-cells, dendritic cells, and eosinophils, are responsible for its production. The corneal epithelium, immune cells, keratocytes, and neurons all express the two isoforms of NK1R, which has the highest affinity for SP. The most recent research supports SP’s contribution to corneal healing by encouraging epithelial cell migration and proliferation. Additionally, when applied to the eyes, SP has proinflammatory effects that result in miosis, intraocular inflammation, and conjunctival hyperemia. In this review article, we examine the role of substance P within the eye. We focus on the role of SP with regards to maintenance and healing of the corneal epithelium.