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Molbank, Vol. 2023, Article M1668: Synthesis of 5-Aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones
Molbank doi: 10.3390/M1668
Authors: Elena V. Steparuk Dmitrii L. Obydennov Vyacheslav Y. Sosnovskikh
A two-stage synthesis of 5-aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones (56–66% overall yields) was carried out by refluxing 5-aroyl-3-(benzyloxy)-2-(het)aryl-4H-pyran-4-ones with ammonium acetate in AcOH and subsequent debenzylation. The prepared N-unsubstituted 4-pyridones exist in the pyridone tautomeric form.
