Molecules, Vol. 28, Pages 2565: Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones

Molecules, Vol. 28, Pages 2565: Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones

Molecules doi: 10.3390/molecules28062565

Authors: Caiyun Yang Sirou Hu Xinhui Pan Ke Yang Ke Zhang Qingguang Liu Xiaobing Xin Jie Li Jinhui Wang Xiaoda Yang

This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines.