Toxics, Vol. 12, Pages 822: Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy

Toxics, Vol. 12, Pages 822: Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy

Toxics doi: 10.3390/toxics12110822

Authors: Ahrum Son Jongham Park Woojin Kim Yoonki Yoon Sangwoon Lee Jaeho Ji Hyunsoo Kim

It is imperative to comprehend the mechanisms that underlie drug toxicity in order to enhance the efficacy and safety of novel therapeutic agents. The capacity to identify molecular pathways that contribute to drug-induced toxicity has been significantly enhanced by recent developments in omics technologies, such as transcriptomics, proteomics, and metabolomics. This has enabled the early identification of potential adverse effects. These insights are further enhanced by computational tools, including quantitative structure–activity relationship (QSAR) analyses and machine learning models, which accurately predict toxicity endpoints. Additionally, technologies such as physiologically based pharmacokinetic (PBPK) modeling and micro-physiological systems (MPS) provide more precise preclinical-to-clinical translation, thereby improving drug safety assessments. This review emphasizes the synergy between sophisticated screening technologies, in silico modeling, and omics data, emphasizing their roles in reducing late-stage drug development failures. Challenges persist in the integration of a variety of data types and the interpretation of intricate biological interactions, despite the progress that has been made. The development of standardized methodologies that further enhance predictive toxicology is contingent upon the ongoing collaboration between researchers, clinicians, and regulatory bodies. This collaboration ensures the development of therapeutic pharmaceuticals that are more effective and safer.