Vaccines, Vol. 11, Pages 415: Evaluation of Transplacental Antibody Transfer in Pregnant Women Immunized with Different SARS-CoV-2 Homologous or Heterologous Schemes

Vaccines, Vol. 11, Pages 415: Evaluation of Transplacental Antibody Transfer in Pregnant Women Immunized with Different SARS-CoV-2 Homologous or Heterologous Schemes

Vaccines doi: 10.3390/vaccines11020415

Authors: Maria Elena Romero-Ibarguengoitia Zulema Lourdes Flores-Salazar Kimberly Dariela Arroyo-García Rafael Soto-Gámez Jessica Andrea Leal-Meléndez Mauricio René Garza-Herrera Gordon Bennett-Vidales Mauricio Hurtado Cabrera Roberto González-Habib Liliann Peña Jiménez Raúl Garza-Bulnes Irene Antonieta Barco-Flores Luis Fernando Castillo-Figueroa Arnulfo Garza-Silva Andrea Rivera-Cavazos Diego Rivera-Salinas Arnulfo González-Cantú Miguel Ángel Sanz-Sánchez

There is scarce information related to transplacental antibody transfer against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with different homologous and heterologous vaccination schemes. This study aimed to correlate the magnitude of transplacental transfer anti-SARS-CoV-2 antibodies in different homologous and heterologous schemes. An observational cross-sectional study was developed to identify pregnant women vaccinated against SARS-CoV-2. They were questioned about their immunization status; blood samples from the mother, umbilical cord during labor, and the newborn 72 h after birth were taken to measure anti-S1 and anti-S2 specific IgG antibodies for SARS-CoV-2. We recruited 104 women with a median age of 29 (SD 1.17). We found antibodies in all newborns with vaccinated mothers. Homologous BNT162b2 mRNA regimen had the highest mean (SD) antibody titers (AU/mL) in maternal (994.93 (3.08), p = 0.039), umbilical cord (1316.43 (2.79), p = 0.016), and newborn (1192.02 (3.55), p = 0.020) blood. The generalized linear model showed a positive effect over antibodies with at least one dose in maternal (β = −1.1, p = 0.002) and newborn (β= −0.717, p = 0.044) blood, and with two doses (β = −0.684, p = 0.026) in umbilical cord blood. In conclusion, antibodies were detected in all vaccinated women and their newborns. Transfer of antibodies was found from the first dose, and the levels increased with the number of vaccine doses. Vaccination should be encouraged in pregnant women with any available scheme.